Napoli see Rasmus Hojlund and Amir Rrahmani return to action, but neither is fit to start, so Antonio Conte is expected to pick Lucca in attack, Sam Beukema and Juan Jesus at centre-back.
Lucca was benched against Inter on Saturday and had received a red card in his latest game as a starter against PSV last week.
Romelu Lukaku, Kevin De Bruyne, Alex Meret and Stanislav Lobotka are injured.
Several sources, including Gazzetta and Corriere dello Sport, report that Scotland international McTominay is expected to rest so Eljif Elmas will join Billy Gilmour and Zambo Anguissa in the middle of the park.
Noa Lang is expected to start for the first time in Serie A this season, completing a three-man attack with Lucca and Matteo Politano.
Milan loanee Francesco Camarda is expected to start for Lecce.
Lecce (4-3-3): Falcone, Veiga, Gaspar, Tiago Gabriel, Gallo; Coulibaly, Ramadani, Maleh; Pierotti, Stulic, Banda.
Napoli (4-3-3): Milinkovic-Savic, Di Lorenzo, Beukema, Juan Jesus, Olivera; Anguissa, Gilmour, Elmas; Politano, Lucca, Lang.
