The Blues travel to Molineux looking to bounce back after their shock home defeat to Sunderland and seal a quarter-final spot.
Enzo Maresca is expected to rotate his side but Chelsea should have more than enough to get through against a Wolves side in free fall under Vitor Pereira.
Hwang Hee-chan and JeanâRicner Bellegarde were both passed fit for Wolves against Burnley, though Leon Chiwome is still out.
Liam Delap is set to be involved for Chelsea for the first time since August after the striker returned to training following a hamstring injury last week but was not ready to face Sunderland.
Maresca has confirmed that he will rotate and utilise his large squad at Molineux, with the likes of Joao Pedro, Enzo Fernandez and Moises Caicedo all set to be rested as they deal with lingering knocks that are preventing them from training fully – along with one or two other unnamed team-mates.
Cole Palmer and Benoit Badiashile are both sidelined until December, while Levi Colwill and Dario Essugo are long-term absentees.
Malo Gusto is back from suspension, while Mykhailo Mudryk remains unavailable.
The setback against Sunderland was unexpected for Chelsea after such a strong recent run as they left themselves simply too vulnerable while chasing a late winner.
But they could barely ask for better opponents in terms of quickly getting back to winning ways.
Wolves – who last won a league game in April – are in turmoil at the moment with simmering frustrations between fans, the manager and players boiling over in ugly fashion at the weekend.
We anticipate another away victory at Molineux, where another toxic evening could lie in wait.